Nattokinase inactivates plasminogen activator inhibitor type 1

Researchers in Japan, working on the fibrinolytic enzyme Nattokinase, found that is breaks up a protein called plasminogen activator inhibitor 1 (PAI-1 or endothelial plasminogen activator inhibitor, or serpin E1).

PAI-1 inhibits tissue plasminogen activator and urokinase – two enzymes that ultimately increase fibrinolysis (the breakdown of fibrin in blood clots).

After treatment with Nattokinase, the PAI-1 lost it’s activity.

Since the enzymes that break up the clots are no longer inhibited, fibrinolysis increases.

This was dose dependent.

The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1.

Urano T, Ihara H, Umemura K, Suzuki Y, Oike M, Akita S, Tsukamoto Y, Suzuki I, Takada A.

J Biol Chem. 2001 Jul 6;276(27):24690-6. Epub 2001 Apr 26.


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I suffered a serious neck injury when I was about 19 years old. That problem didn't affect me until I was in my 40s, but I then suffered two prolapsed discs in my neck and problems with my right arm and hand. Serrapeptase was recommended by my chiropractor to try to break up the scar tissue around the vertebrae that were causing me the problems. It seemed to help me with my problem, so created this site to help inform people what serrapeptase is, what it can do and just as importantly, what it cannot do. I hope you find the information useful.

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