Back in 1990, when research was underway on Nattokinase, Japanese researchers found:
- A fibrinolytic enzyme now known as Nattokinase was present in Natto.
- Oral administration of nattokinase caused fibrinolytic activity in the plasma.
- Given orally to dogs, nattokinase broke down experimentally induced blood clots.
Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase.
Sumi H, Hamada H, Nakanishi K, Hiratani H.
Acta Haematol. 1990;84(3):139-43.
These experiments and other like them paved the way for nattokinase to be accepted as a possible treatment for patients with a higher chance of blood clots.