In a study in the Indian Journal of Pharmaceutical Studies, researchers investigated the anti-inflammatory properties of three proteolytic enzymes – chymotrypsin, trypsin and serratiopeptidase (serrapeptase).  They looked at hind paw edema (swelling due to fluid accumulation) and cotton pellet induced granuloma (inflammation due to tissue injury) in albino rats.  They also looked at any possible interactions with aspirin.

All three protease showed does-dependent anti-inflammatory properties (the higher the dose, the more anti-inflammatory the response).

Of the three protease enzymes, serrapeptase showed the highest anti-inflammatory activity.  All three proteases showed synergistic effects with aspirin.

Read the article here.