Serrapeptase and Cancer 17

The enzyme serrapeptase (which is sometimes referred to as serratiopeptidase) is often described as a magic bullet for cancer. That's an overstatement, but there is a growing body of anecdotal evidence than serrapeptase can be very helpful for achieving remission and staying in remission from cancer, if it is used at the right time and in the right dosage. But first let's start with an explanation of why several kinds of proteolytic enzymes make a difference in beating cancer and staying in remission for good.

Cancer Is Its Own Worst Enemy

yellow-cancer-awareness-ribbonEnzyme therapy for cancer, at least for the kinds of cancer that form solid tumors, takes advantage of the fact that a cancerous tumor is its own worst enemy. The outer layers of a tumor push into neighboring healthy tissues. The inner core of a tumor is always fighting with the outside of a tumor for oxygen and nutrients.

Cancerous tumors have an unusual ability to use sugar without oxygen to make energy, but at some point the innermost reaches of a cancerous tumor will have too little oxygen even for cancer cells. These interior cells will start to die off. But it's the death of cells in the middle of the tumor that makes it harder for the immune system to fight the stronger cancer cells on the outside of the tumor.

Why Killing Part of a Tumor Sometimes Helps the Rest Survive

The human immune system kills cancer cells with a substance known as tumor necrosis factor. This substance is also known by its abbreviation, TNF.

Made by specialized white blood cells known as macrophages, TNF from these white blood cells locks onto a receptor site on a cancer cell. The place where TNF attaches itself to the cancerous cell is known as the death domain.

Activating the death domain forces the cancer cell to send out chemicals that help the immune system locate it. The activation of this segment of DNA also triggers a process called apoptosis, or “cellular suicide” in the cancer cell. And it makes the cancer cell more vulnerable to irritant chemicals that inflame its outer membrane and start snipping their proteins into tiny pieces.

The death domain even sends out signals to other white blood cells known as neutrophils to join in the attack. These neutrophils travel through mucus or lymph or on the linings of healthy organs to reach the cancerous tumor. Eventually the macrophage can surround and consume a cancer cell, recycling its components as nutrients.

As hard as it is to fathom, nearly everyone has this process going on at one time or another, even if he or she does not develop diagnosable cancer. When a cancerous tumor is still just a cluster of 1,000 to 10,000 cancerous cells, TNF and the immune system usually can kill it.

Some scientists estimate that 50% of the population has at least one of these micro-tumors somewhere in the body at any given time. Chances are your own body has created several would-be cancerous tumors at some time in your own life. But the TNF system can be a victim of its own success.

The system works well unless there are just so many cancerous cells breaking down at the same time that the immune system can't locate the tumor. That's when the immune system needs the help of enzymes to clear the field so it can focus on killing cancerous cells.

Enzymes to Clear Out the Debris of Cancer

Most of us know that enzymes help us digest our food. While there are thousands of different enzymes with tens of thousands of important functions in the human body, not just digesting food, the enzymes that are the most important to treating cancer are those enzymes that help break down proteins like the proteins that are also broken down by the cancer-fighter TNF. These enzymes are known as proteolytic enzymes.

It's well-established principle in enzyme biology that proteolytic enzymes fight cancerous tumors. Back in the 1920's, a physician named Dr. Max Wolf noticed that people who have cancer tend to lack proteolytic enzymes in their digestive tracts. The reason for this is that these enzymes are busy helping the immune system fight cancer (not that cancer is caused by not getting enough enzymes).

Dr. Wolf and his coworker Dr. Helen Benitez started isolating digestive enzymes and then using them as a treatment for cancer. They developed a treatment that has been used by approximately 25,000,000 cancer patients over the last 80 years called Wobenzym.

Fighting Fibrin (and Cancer) with Wobenzym

Wobenzym is a combination of six proteolytic enzymes, trypsin, chymotrypsin, pancreatin, rutin, bromelain, and papain. When these enzymes get into the bloodstream, they help break up the cellular debris caused by all kinds of inflammation, including the inflammation the immune system uses to fight cancer. These enzymes act as a kind of clean-up crew that allows macrophages to lock onto cancer cells and finish the process of their destruction.

In particular, these enzymes break down a substance called fibrin. This is the protein that holds a tumor together, and keeps the immune system from getting inside the tumor. Fibrin helps the tumor grow its own blood supply. And fibrin hides the tumor from both neutrophils that would spray it with irritant chemicals and macrophages that would eventually surround and consume dead or dying cancer cells.

The ability of enzymes to break down fibrin “de-cloaks” the cancer tumor. When a tumor's outermost layer is covered with a layer of the fibrin-like substance known as fibrinogen, the immune system may not be able to find it. When fibrin breaks down, the immune system breaks in and destroys the tumor.

Or at least that is what Drs. Wolf and Benitez always thought was happening. They only knew for sure that their cancer patients were more likely to recover when they were given the enzyme formula. It wasn't until 1993 that anyone ran a clinical trial.

After 73 Years, Enzymes Get a Clinical Trial

In the early 1990's, the National Cancer Center invited a Manhattan-based cancer specialist named Dr. Nicholas Gonzalez to run a test of enzymes as a treatment for cancer of the pancreas. The National Cancer Institute chose to test enzyme products on pancreatic cancer because there is usually very little that conventional medicine can do for it. Only 1 in 20 people diagnosed with pancreatic cancer lives five years after diagnosis, and 76% die within the first year after diagnosis.

But the patients of Dr. Gonzalez lived a lot longer. Of his patients taking enzymes, 81% lived longer than one year (compared to 24% with conventional treatment), 45% lived two years, and 36% lived three years. In 2010, Dr. Gonzalez reported he had a patient survive inoperable pancreatic cancer for a full 20 years. (Robert Rister, a medical friend of mine, met her in 2001, and she seemed quite healthy at the 11-year mark.)

So why isn't enzyme therapy standard procedure for cancer? It turns out there are a few complications.

Merging Enzyme Therapy with Conventional Cancer Treatment

While it is unquestionably a good thing to break up cancer tumors, most cancer patients have a lot going on in their bodies. They may be given strong antibiotics to prevent infections. They may be put blood thinning medications to fight the blood clots that these antibiotics can cause to form.

Doctors who are not convinced of the power of enzyme therapies are very hesitant to try them because of the need to prevent both clots and bleeding. Most doctors want to see the results of treating tens of thousands of patients under controlled conditions—the fact that 25 million patients have been treated under uncontrolled conditions isn't enough—before they give up on conventional chemotherapy and radiation, despite the miserable track record of these methods for treating most kinds of cancer.

And because enzyme therapy isn't mainstream, it is almost never covered by insurance.

Which Enzymes Are Used in Cancer Therapy?

Enzyme therapy for cancer isn't a do-it-yourself project. You have to let your doctor know you are using enzymes because of issues like preventing clots and bleeding. However, there have been some really amazing results form taking a combination of:

  • 1 mg of chymotrypsin,
  • 24 mg of trypsin,
  • 45 mg of bromelain,
  • 50 mg of rutin,
  • 60 mg of papain, and
  • 100 mg of pancreatin (at strength of 8 x USP)

every day for 2 weeks to 4 years.

The combination of enzymes slowed the progression and spread of:

  • Pancreatic cancers,
  • Lung cancers,
  • Cervical cancers,
  • Head and neck cancers,
  • Oral cancers, and
  • Colon cancers.

People lived longer and had fewer side effects over a period of up to 5 years when they took this simple and inexpensive combination of enzymes under a doctor's supervision. Tests of another combination of just five enzymes yielded similar results. But where does serratopeptidase (serrapeptase) fit in?

Serrapeptase in Cancer Therapy

Serratiopeptidase is even stronger than bromelain, papain, trypsin, chymotrypsin, rutin, and pancreatin. That's exactly why you don't use it in fighting active cancer!

Enzymes don't actually kill cancer cells. They just help the immune system find cancer cells. Weaker enzymes clean up cellular debris so that macrophages can identify, engulf, and destroy cancer cells. Stronger enzymes like serratiopeptidase would break up so many cancer cells that the field-clearing benefits of weaker enzymes would be canceled out.

That doesn't mean that cancer patients would never use serratiopeptidase at all. After a cancer has gone in remission, then serratiopeptidase helps clean up scar tissue. It helps deal with swelling. It helps to relieve pain.

All of these are very positive benefits that help you stay in remission. But it's other enzymes that help you get into remission first.

About Andy

I suffered a serious neck injury when I was about 19 years old. That problem didn't affect me until I was in my 40s, but I then suffered two prolapsed discs in my neck and problems with my right arm and hand. Serrapeptase was recommended by my chiropractor to try to break up the scar tissue around the vertebrae that were causing me the problems. It seemed to help me with my problem, so created this site to help inform people what serrapeptase is, what it can do and just as importantly, what it cannot do. I hope you find the information useful.

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17 thoughts on “Serrapeptase and Cancer

  • Jen

    Hi Andy,

    Thanks for the article. I am interested in learning more about the combination of enzymes that you list above. Could you provide some detail about the sources of each? I am now vegan (although I do home brew kefir), so I would like to get an idea of how I can supplement those enzymes in vegan form. I have recently found VeganZyme but have not yet tried it.

    Thanks again.


  • Karl

    I’ve just read your article concerning which enzymes to use for tumours. My Golden Retriever has a nasal tumour. He has been prescribed homoeopathic remedies by an vet who practises natural medicine. Along with with herbal supplements, he recommended using Serrapeptase. we’ve given our dog three a night for the past five months. About five days ago, pieces of tissue about 5 or 6cm in length started coming out from between his lip and gums, just below the area of swelling on the side of his nose. The first day about five pieces came out. Now it’s down to one or two a day. There was bleeding but this only lasted moments. ould the Serrapeptase be causing this? He is also taking curcumin and other anti tumour supplements.


      • Karl

        Hi Andy,
        My vet said he has got some good results with this enzyme. A friend of his had a fibroid cyst in her breast. He claimed the cyst shrank after using Serrapeptase. I was just curious to gety someone elses opinion especially as the article above recommends using different enzymes for tumours.

  • jm

    I don’t understand the comment about how Serrapeptase should not be used with active cancer. The argument seems to be that it would obviate the need for other enzymes. I don’t get it. It is admitted that Serrapatase would break up cancer cells. Is that not what one wants?

    Please explain.



    • Karl

      No need to get snotty with me. I was merely asking for some advice and opinions on the subject. That was all. As it happens it’s an academic question now anyway, as my Golden Retriever is no longer with me.


  • Jennifer


    So sorry that you lost your dog! Don’t understand who was throwing their snot at you but maybe it’s not posted? Anyway, jm brought up a really good question that I was hoping that Andy or anyone else with experience and knowledge on the matter would answer, as to why the serra enzyme is best only to clear the scar tissue, as opposed to break up/fight the active cancer. Either way, I respect anyone’s opinion, of course. 🙂


  • Julie Spangler

    I also don’t understand why taking Serrapeptase is not used in fighting cancer as jm asked. Also, what if I start taking Serrapeptase and I have cancer that I don’t know about? What happens at that point? It sounds scary to take it and I’m taking a risk that I don’t have cancer.

  • Luna Rossi

    Great post, thank you so much Andy! I was thinking of using Serrapeptase to help my mother who has a tumour, and luckily I have found your article which has opened to a whole new enzymatic therapeutic world 🙂

    Best wishes,

  • Julie

    I only have one kid and unfortunately in January this year my 28 year old son had a brain aneurysm and subsequent brain surgery. the surgery went perfectly. However the scar tissue that developed a few months later is causing him to have grand mall seizures. He has to take 3 different seizure meds to keep him from having seizures. We have talked to people we have met who have had family members on these anti seizure meds who end up losing their memory and mental abilities to the point of senility after 10 years on the meds. My son has already lost an obvious amount of his memory abilities after being on the drugs for 11 months.
    My thought was that perhaps serrapeptase and or nattokinase would help break down the fibrin in the scar tissue in his brain. I read somewhere that one of these enzymes crosses the blood brain barrier.
    Will you point me in the direction of someone who would have an informed opinion about the probability of this working and also the possible downsides of using these enzymes?
    Thank you so much, Julie

  • Dennis Scianna

    So you’re saying serrapeptase is not going help in the cancer killing battle, unless you’re in remission. So what can you offer to reach remission for stage 4 lung cancer.

  • Joanne

    I’ve just read this after a diagnosis that my mom got a 7cm lung cancer..would this benefit her also where to get it from also the intake daily