Back in 1990, when research was underway on Nattokinase, Japanese researchers found:
- A fibrinolytic enzyme now known as Nattokinase was present in Natto.
- Oral administration of nattokinase caused fibrinolytic activity in the plasma.
- Given orally to dogs, nattokinase broke down experimentally induced blood clots.
These experiments and other like them paved the way for nattokinase to be accepted as a possible treatment for patients with a higher chance of blood clots.