Can You Use Serrapeptase and Nattokinase Together?

Serrapeptase and nattokinase are entirely different enzymes. They both are proteolytic enzymes, which is to say they both break down proteins, particularly fibrin in the bloodstream. They both originally came from natural sources in China and Japan, serrapeptase from silkworms and nattokinase from the fermented soy food natto. But they don’t do quite the same things in the human body.

pillsSerratiopeptidase breaks down collagen and fibrin. It can help the body “clean out” broken tissue in bones, muscles, tendons, and ligaments. It is especially useful for breaking down fibrin. This helps the body dissolve blood clots. That can be very helpful in healing bruises. And it prevents the formation of scar tissue so that joints retain their range of motion as they heal.

Nattokinase is partially broken up in the process of digestion. The pure nattokinase that passes into the bloodstream also dissolves the protein fibrin. This prevents or corrects some of the problems that are caused by blood clotting, but nattokinase does not break down damaged collagen.

Nattokinase fragments, however, can do something that serratiopeptidase cannot. They act as an angiotensin converting enzyme (ACE) inhibitor. They prevent the hormone angiotensin from being converted into the hormone angiotensinogen, which raises blood pressure. Just how much nattokinase lowers your blood pressure depends on how thoroughly it is digested. If you are taking antacids for heartburn, for instance, your stomach will produce less acid and the nattokinase will be less thoroughly broken down into fragments. It will have more of a blood thinning effect than a blood pressure lowering effect.

Some supplements combine serratiopeptidase with nattokinase. There are some people for whom this is a good combination. If you exercise as part of your routine for controlling your blood pressure and you suffer an injury, it is going to be harder to keep your hypertension in check while you are recovering.

Serratiopeptidase supports recovery of muscles, bones, and connective tissues, while nattokinase might give just that tiny boost in blood pressure control that makes the difference that keeps you from having to take more medication or adding a new medication. Don’t take nattokinase if you take aspirin for your heart or if you are on prescription anticoagulant (blood thinning) medication. There is very little risk of an adverse reaction, only one adverse reaction reported in the medical literature, but the combined effects are impossible to predict.

And if you don’t have high blood pressure, serratiopeptidase and nattokinase are redundant. Because serratiopeptidase is a stronger and more versatile proteolytic enzyme, and it doesn’t just dissolve fibrin, it is the enzyme you need.

About Andy

I suffered a serious neck injury when I was about 19 years old. That problem didn't affect me until I was in my 40s, but I then suffered two prolapsed discs in my neck and problems with my right arm and hand. Serrapeptase was recommended by my chiropractor to try to break up the scar tissue around the vertebrae that were causing me the problems. It seemed to help me with my problem, so created this site to help inform people what serrapeptase is, what it can do and just as importantly, what it cannot do. I hope you find the information useful.

Comments

  1. Hi Andy, do you take Serrapeptase daily?? For example can I take it for a few days after I work out and then stop or when I have more pain than ususal??
    At this time I am taking Nattokinase with K2 for borderline blood pressure..
    Thanks for you input
    Art

    • I have taken it daily for several months with no problems. I was taking it for scar tissue in a spinal injury. I no longer take it, but it is an enzyme, and can only work on the problems when it is in your body, so for me, I’d take it none stop for a while.

  2. I have years old scars on my hand. Does it will help me huh ?

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