I have seen it written many times on the web, where one person suggests serrapeptase as a treatment for some condition, only to be attacked by someone else stating that serrapeptase doesn’t work because it will be broken down in the gut like every other enzyme and end up as amino acids in the blood.

Advances in coating proteins to pass through the digestive tract intact has done little to reassure the doubters.  I have found and article published in the Biotechnology and Applied Biochemistry journal where researchers looked at intestinal absorption of serrapeptase in rats.

After rats were given 100mg/Kg serrapeptase orally, serrapeptase did appear in the blood, with peak levels between 30 minutes and 2 hours.  The serrapeptase in the blood as examined by proteinase assay to determine it’s structure.

Results indicated that orally taken serrapeptase was absorbed from the intestines into the blood in an enzymically active form.

Read the paper here.